GRAW 2 takes place in 2014 and follows the events of the original GRAW. Insurgent rebel forces have sent Mexico into a nationwide civil war, which poses a threat to the United States. Scott Mitchell and his fellow Ghosts are called on to neutralize the potential risk to the US, and will have to fight on both sides of the border, including in El Paso, Texas, to be successful.

Ubisoft promises GRAW 2 will include changing weather systems, improved artificial intelligence, an advanced Cross-Com system, and more types of military support, including air strikes from jet fighters. There will also be new weapons and a new soldier class, the Medic.